How to Start CAR T Cell Therapy Infusion at a Hospital: A Comprehensive Guide
Starting CAR T-cell therapy in a hospital requires a multidisciplinary approach. First, obtain regulatory approvals and establish partnerships with accredited cell-processing facilities. Train staff in patient selection, apheresis, and infusion protocols. Develop infrastructure for cryopreservation, handling, and monitoring of CAR T cells. Implement stringent safety measures for cytokine release syndrome (CRS) and neurotoxicity management. Finally, ensure post-infusion follow-up and establish financial planning for therapy accessibility and sustainability.
Types of Vectors Used in CAR T Cell Therapy
Chimeric Antigen Receptor (CAR) T cell therapy relies on genetic engineering to enable T cells to target and destroy cancer cells. A crucial step in this process is introducing the CAR construct into T cells, which is achieved using vectors.